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Case Reports of Two Sisters with Corticoid Deficiency Unassociated with Hypoaldosteronism

THOMAS H. SHEPARD, M.D.; BENJAMIN H. LANDING, M.D.; DAVID G. MASON, M.D.

AMA J Dis Child. 1959;97(2):154-162.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Although familial Addison's disease has been previously reported, it is usually associated with hypoparathyroidism or with congenital adrenal hyperplasia. Familial Addison's disease by itself is rare. Recent case reports by Whitaker et al.¹ and DiGeorge and Paschkis² have reviewed the subject of hypoparathyroidism and Addison's disease. The Addisonian-like aspect of the familial disease, congenital adrenal hyperplasia, has been reviewed by Iversen,³ Grumbach and Wilkins,⁴ and Childs et al.⁵

Reports of familial Addison's disease have been reviewed. Fleming and Miller⁶ and Croom,⁷ in 1900 and 1909, respectively, reported family members who were weak and pigmented and who were felt on the basis of clinical observation to have Addison's disease. Rolleston⁸ mentions the syndrome as occurring in two sisters. Smith and Higgins⁹ diagnosed the disease in two brothers because of pigmentation and decreased serum sodium. Wakefield and Smith¹⁰ reported an excessively pigmented man who at autopsy had adrenal atrophy, possibly secondary to . . . [Full Text PDF of this Article]

Author Affiliations

Department of Pediatrics, University of Washington School of Medicine (Dr. Shepard); Department of Pathology of the Children's Hospital and Children's Hospital Research Foundation, University of Cincinnati College of Medicine (Dr. Landing), and Department of Pathology, Providence Hospital (Dr. Mason).

Footnotes

The aldosterone determinations were supervised by Dr. John Leutscher, and the blood corticoid determinations were supervised by Dr. Vincent Kelly. Dr. Richard Koch made available the initial laboratory studies performed in Case 2.

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