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Early Diagnostic Criteria of Congenital HypothyroidismA Comprehensive Study of Forty-Nine Cretins
GEORGE H. LOWREY, M.D.;
RICHARD H. ASTER, M.D.;
EDWARD A. CARR, M.D.;
GOVIND RAMON, M.B.B.S.;
WILLIAM H. BEIERWALTES, M.D.;
NORMA R. SPAFFORD, A.B.
AMA J Dis Child. 1958;96(2):131-143.
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It seems clearly evident that the earlier the diagnosis of congenital hypothyroidism is established and adequate therapy is begun the more satisfactory is the prognosis. In a series of 49 cretinous patients seen at the University Hospital the average age at the time of diagnosis was 12 months. We believe that in most of these cases a diagnosis could have been made before 6 months of age. A survey of these patients revealed that 54% had at least three prominent symptoms of their disease by the end of the first month of life and 75%, by the end of the third month. At present there are generally available laboratory studies that can confirm a suspicion of congenital hypothyroidism in better than 90% of cases. Most of the pediatric textbooks and more extensive reference works pay little attention to the early time of appearance of the several important, though nonspecific symptoms
. . . [Full Text PDF of this Article]
Author Affiliations
Ann Arbor, Mich.
From the Departments of Pediatrics and Internal Medicine, University Hospital. Present Addresses: Massachusetts General Hospital, Boston (Dr. Aster); Northeastern Frontier Agency, Posighat, India (Mr. Ramon).
Footnotes
Submitted for publication March 10, 1958.
This project received support through grants from the Michigan Memorial Phoenix Fund, Michigan Human Resources and Developmental Fund, and American Cancer Society.
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