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L. D. ZEIDBERG, M.D.; R. S. GASS, M.D.; R. H. HUTCHESON, M.D.

AMA J Dis Child. 1957;94(2):179-184.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The placental transmission of immune antibodies to the newborn had been inferred by clinical observation for some years before Ehrlich proved its occurrence experimentally in 1892.¹ Since that time the transplacental passage of humoral antibodies has claimed the interest of many investigators who have made highly significant contributions to the basic knowledge of placental physiology and immunology. Practical results of their work have come from a clearer understanding of the previously observed neonatal immunity of many infants to infections which attacked them later in life. The relatively short duration of the newborn's passively acquired immunity has been well established by many of these investigations,^2-17 and a pattern of artificial immunization for infants has been devised as a result. The practice of actively immunizing expectant mothers in order to protect newborn infants was advocated even in the pre-Ehrlich era ¹⁸ and has been proposed anew in more recent times. . . . [Full Text PDF of this Article]

Author Affiliations

From the Tennessee Department of Public Health and the Department of Preventive Medicine of Vanderbilt University School of Medicine.

Footnotes

This study was supported in part by a grant (E-521) from the National Microbiological Institute of the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare.

After this paper was submitted it was learned from Dr. Charles E. Smith that he and his co-workers had reported evidence of the placental transmission of coccidioidomycosis complement-fixing antibodies in the Am. J. Hyg. 52:1 (July) 1950, and in J. A. M. A. 160:546 (Feb. 18) 1956.

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