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L. VAN MIDDLESWORTH, Ph.D., M.D.

AMA Am J Dis Child. 1954;88(4):439-442.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THYROID function of the newborn was studied by Danowski and co-workers¹ and by Man and co-workers,² who determined the plasma level of the thyroxine-like protein-bound iodine and butanol-extractable iodide. In infants 1 to 3 days old protein-bound iodine averaged 12.0 per 100 cc., and butanol-extractable iodine in infants of 2 to 6 days was 7.0 to 11.7 per 100 cc. These results are compatible with hyperthyroidism in adults or older children.² Several reports * indicated that I¹³¹ uptakes by the thyroids of normal children "less than 1 year" to 14 years of age were well within the broad range of normal adults, i. e., less than 50% of the injected dose of I¹³¹ accumulated in the thyroid area after 24 or 48 hours.

Apparently, no I¹³¹ studies have been reported on newborn infants. The absence of such studies results partly from the previous . . . [Full Text PDF of this Article]

Author Affiliations
MEMPHIS

From the Department of Physiology, University of Tennessee College of Medicine and the John Gaston Hospital.

Footnotes
This work was supported by a grant from the Atomic Energy Commission.

References 3-6.

One microcurie of I131 in a thyroid weighing 2.4 gm. will produce a maximum total radiation of 60 r (rep), or 144 gm.-r (grams x roentgen equivalents physical). A gastrointestinal x-ray series with fluoroscopy in an infant results in exposure to at least 20 r, or 3,600 gm.-r. The treatment of thyrotoxicosis in an adult with a 30-gm. thyroid will usually require 5,000 r (rep), or 150,000 gm.-r, from I131 given as a single dose.

The scintillation tube was obtained from Nuclear Research Corp., Grays Ferry Ave., Philadelphia. A discriminator and preamplifier was built by B. P. McKay, Research Associate, University of Tennessee.

Sterile tracer solution (obtained from Abbott Laboratories, North Chicago), 250 µc of I131 per cubic centimeter.

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