
VARIATION IN DIPHTHERIA ANTITOXIN TITERS OF HUMAN SERUMREPORT OF AN EXTENDED STUDY, WITH SPECIAL REFERENCE TO AN ENDOCRINE AND VITAMIN RELATIONSHIP
MARY M. SCHMECKEBIER, M.D.
Am J Dis Child. 1943;66(1):25-36.
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The literature records few determinations at frequent intervals of the diphtheria antitoxin titer of the blood serum of the same person over a period of several years. In 1925 Hamburger1 reported a study of 6 subjects on whose blood serum antitoxin determinations were done on several occasions. No more than five determinations were done on any 1 subject, and the longest interval between the initial and the final determination of the antitoxin titer was one and one-half years. In 1 subject there was an increase in the antitoxin titer from 0.01 to 0.75 unit per cubic centimeter within two and one-half months without any apparent stimulus. In the other subjects there was considerably less variation. In 1929 Fitzgerald2 published a paper on variations in the antitoxin content of serums of 6 adults over periods of from one to six years. In this article the amount of antitoxin in
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Author Affiliations
SAN FRANCISCO
From the Children's Hospital and the George William Hooper Foundation for Medical Research of the University of California.
Footnotes
E. Charles Fleischner Endowment Fund Fellow.
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