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MORRIS SIEGEL, M.D.

Am J Dis Child. 1938;56(6):1294-1303.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

For about twenty-five years, ever since the earliest attempts to prevent whooping cough by the use of specific vaccines, there have been conflicting reports¹ as to their value. In efforts to make the vaccine more effective, changes were made in the method of preparation² and in the dose.³ The trend has been toward the use of increasingly larger doses of vaccines prepared from virulent or phase I strains.^2b The dose has been increased since 1912 from less than a billion bacilli⁴ to 80 and 100 billion bacilli^1c and more.⁵ As for the method of preparation, Sauer has placed a great deal of emphasis on the necessity of employing recently isolated strains in preference to stock strains, even though their antigenicity has been maintained under suitable cultural conditions.⁶ In addition, some investigators⁷ have emphasized the immunizing value of toxic substances in cultures . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Bureau of Laboratories of the Department of Health of New York City.

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