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JOHN A. TOOMEY, M.D.; WILLIAM S. TAKACS, B.S.

Am J Dis Child. 1938;56(6):1274-1279.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It has been shown that cholesterol inactivates the virus of poliomyelitis either by adsorption or by destruction.¹ Cholesterol is derived from animal sources. Perhaps ergosterol would act likewise. The latter is obtained from ergot or yeast and has the same hydrocarbon filament as cholesterol, but with an additional methyl group in the side chain and with two additional double bonds, one in the side chain and the other in the nucleus.

METHODS AND MATERIALS

In the following experiments, the same technic was employed as in previous experiments with cholesterol.¹

A quantity of a 1 per cent suspension of Flexner's eluted mixed virus² together with a quantity of ergosterol³ equal in weight to 10 per cent of the total volume used was ground for twelve hours in a ball mill that had been placed in the refrigerator. The test dose was 0.15 cc. of the supernatant fluid . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Department of Pediatrics of Western Reserve University and the Division of Contagious Diseases of City Hospital.

Footnotes
Aided in part by a grant from the Marion R. Spellman Fund of the Cleveland Foundation.

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