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II. NEUTRALIZING EFFECT AGAINST VARIOUS STRAINS OF VIRUS

JOHN A. TOOMEY, M.D.

Am J Dis Child. 1938;55(6):1261-1266.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Two types of an experimental antiserum have been obtained from horses: one produced by injecting pure eluted poliomyelitis virus as the antigen and the other by injecting pure eluted virus fortified by the addition of enteric toxins and organisms.¹ The fortified antigen produced a better neutralizing serum (1:800 to 1:1,000) than did the plain virus (1: 200 to 1: 250) against Flexner's M. V. strain.

Since it has been stated that two or three strains of poliomyelitis virus exist, it is obvious that to be of any practical value an antiserum should have some neutralizing value against each strain.

Serums described previously¹ were tested against other strains. These serums (3732 and 3757) were obtained from a horse which had been inoculated with fortified antigen and from one that had been inoculated with plain virus antigen. The serums were obtained between May and September 1936, and from eight to . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Department of Pediatrics, Western Reserve University, and the Division of Contagious Diseases, City Hospital.

Footnotes
This work was made possible through a grant from Parke, Davis Co., Detroit.

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