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ARTHUS OR SHWARTZMAN PHENOMENON?

JEROME L. KOHN, M.D.; EDWARD J. McCABE, M.D.; JACOB BREM, M.D.

Am J Dis Child. 1938;55(5):1018-1030.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1903 Arthus¹ observed characteristic changes in rabbits which were given subcutaneous injections of horse serum at weekly intervals. The successive injections were not given in the same site. The reactions varied from slight infiltration to induration and even gangrene. These reactions became successively worse after the third injection, becoming gangrenous after about the eighth injection. Arthus¹ commented that perhaps human beings also were susceptible to the reaction he described, and he cautioned against repeated injections of horse serum. Pirquet and Schick² in 1905 described the occurrence of local edema at the site of the second injection in patients who had been previously treated with antitoxic horse serum. They reported one case of necrosis of the skin.

In the last ten years many authors (Gatewood and Baldridge,³ Tumpeer, Matheson and Straus,⁴ Hegler,⁵ Irish and Reynolds,⁶ Maroney,⁷ Ross⁸ and Meleney⁹) have reported . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK; BOSTON

From the Willard Parker Hospital for Contagious Diseases, Department of Hospitals, New York.

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