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II. NEUTRALIZATION OF ANTIGEN

WILLIAM M. SCHMIDT, M.D.; VERNON W. LIPPARD, M.D.

Am J Dis Child. 1937;54(4):777-785.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since publication of the results of the experiments of Prausnitz and Küstner in 1921,¹ many investigators have studied the behavior of mixtures of allergic serum and antigen. The evidence indicates that serum capable of conferring passive local sensitization conforms in many respects to the characteristics of an antibody; such serum may be neutralized by its specific antigen, either in vivo or in vitro or possibly in both. Neutralization of antigen by its specific passive transfer antibody has been observed,² but the conditions which are necessary for its demonstration appear to warrant further investigation.

In several investigations,³ mixtures containing arbitrary amounts of serum and antigen were used without due regard to the quantitative relationships involved. Jadassohn^2a clearly pointed out that properly planned antigen neutralization experiments require concentrations of antigen within the neutralizing capacity of the serum used.

The method of titration of antibody described by Woringer⁴ . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the New York Hospital and the Department of Pediatrics, Cornell University Medical College.

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