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V. PROTHROMBIN; QUANTITATIVE AND QUALITATIVE STUDIES OF PLATELETS IN THE NORMAL INFANT

ELEANOR I. LESLIE, M.D.; HEYWORTH N. SANFORD, M.D.

Am J Dis Child. 1936;51(3):590-593.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a former report concerning the substances involved in the coagulation of the blood of the new-born,¹ the prothrombin was estimated by a comparison of the time necessary for plasma treated with sodium oxalate to clot after various amounts of calcium chloride were added, as described by Howell.² During the course of further experimentation in this field, we became dissatisfied with this method.

Whether the platelets alone are the source of prothrombin is still open to considerable controversy. However, as plasma from which all platelets have been removed will not clot for a great length of time and, conversely, plasma containing a high concentration of platelets coagulates rapidly, it seems fair to assume that the platelets are at least the principal source of prothrombin. For this reason the following studies were made.

METHOD

Our previously described method³ for obtaining natural venous plasma was used. Platelet counts were . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Pediatrics, Rush Medical College, and the Presbyterian Hospital.

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