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SPLENOHEPATOMEGALY ASSOCIATED WITH WIDESPREAD HYPERPLASIA OF NONLIPOID-STORING MACROPHAGES; DISCUSSION OF THE SO-CALLED RETICULO-ENDOTHELIOSES

ARTHUR F. ABT, M.D.; EDWARD J. DENENHOLZ, M.D.

Am J Dis Child. 1936;51(3):499-522.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In reviewing the literature in an attempt to identify the condition in the case which we are here reporting, we have found that Letterer,¹ in 1924 under the title "Aleukämische Retikulose (Ein Beitrag zu den proliferativen Erkrankungen des Retikuloendothelialapparates)," described the occurrence of splenohepatomegaly, associated with anemia, and a purpuric eruption in a 6 month old infant. The child died four days after admission to the hospital, and at autopsy the histologic examination revealed a unique and surprising condition. In the liver, spleen, lymph nodes, bone marrow and skin there was a proliferation of large, pale reticulo-endothelial cells, invading and replacing the normal structure of these.organs.

Following the publication of Letterer's article, several quite similar cases were reported, but it was not until 1933 that Siwe,² in describing a similar case in a 16 month old infant in an article entitled "Die Reticuloendotheliose—ein neues Krankheitsbild unter den Hepatosplenomegalien," . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Sarah Morris Hospital for Children, Michael Reese Hospital.

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