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REPORT OF TREATMENT WITH THE ANTERIOR PITUITARY-LIKE GONADOTROPIC HORMONE FROM THE URINE OF PREGNANT WOMEN

GEORGE B. DORFF, M.D.

Am J Dis Child. 1935;50(3):649-660.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1932, Engle¹ demonstrated that the use of an extract of the anterior lobe of the pituitary gland or of the urine of pregnant women in immature rats and monkeys caused a definite increase in the size of the testes. This was due to an increase in tubular growth and in interstitial cellular mass. However, no change in gametogenesis was noted by him in his experiment. He suggested the possible application of this phenomena to the human being.

As a result of Engle's work, Goldman and Stern² proceeded with a study on human beings and demonstrated the effectiveness of the anterior pituitary-like gonadotropic hormone on the undescended testes of two adolescent boys. B. Schapiro³ had obtained good results in a group of males presenting hypoplastic and undescended testes by the use of a commercial gonadotropic preparation.⁴

Subsequently, Brosius and Schaffer⁵ produced spermatogenesis in a man . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN

From the Endocrine Clinics of the Department of Pediatrics, the New York University Medical College, the Children's Medical Service of the Third Medical Division, Bellevue Hospital and the Beth-El Hospital.

Footnotes
Presented before the New York Endocrinological Society, Jan. 23, 1935.

Presented at the Nineteenth Annual Convention of the Association for the Study of Internal Secretions at Atlantic City, N. J., June 11, 1935.

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