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NOTES ON THE LACK OF RELATIONSHIP BETWEEN THE LEVEL OF PLASMA PHOSPHORUS AND THE RACHITIC STATE

JOSEF WARKANY, M.D.

Am J Dis Child. 1935;49(2):318-326.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

For many years after Iverson and Lenstrup¹ and Howland and Kramer² found low values for inorganic serum in rachitic children, this change in blood chemistry was regarded not only as a constant symptom but also as an etiologic factor in active rickets. However, in the last few years several investigators have concluded that certain clinical as well as experimental observations indicate a lack of relationship between the development and cure of rickets and the concentration of inorganic phosphorus in the blood. In 1922 Hess and Unger³ stated that normal values for inorganic blood phosphorus are occasionally found in rickets. In an experimental study in rats, Hess, Weinstock, Rivkin and Gross⁴ pointed out:

Rickets may be associated with normal concentrations of inorganic phosphorus in the blood. If milk is incorporated in a standard rickets-producing ration and small amounts of irradiated ergosterol are added, the inorganic phosphorus is . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI

From The Children's Hospital Research Foundation and the Department of Pediatrics, College of Medicine, University of Cincinnati.

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