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JOHN E. DUNLAP, M.D.

Am J Dis Child. 1934;47(3):578-585.

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Pituitary dysfunction, usually of the hyposecretion type, occurring in children before or during adolescence, is not a rarity. The result of this hyposecretion, however, is, in the majority of cases, obesity with genital and secondary sexual retardation. I shall present a case of hyposecretion of the anterior lobe resulting in emaciation with marked genital and secondary sexual retardation. Lorain,¹ in 1871, published the first exact clinical description of this type of infantilism, but he did not associate the condition with a lesion of the pituitary gland. De Sanctis, in 1905, first associated this form of infantilism with an abnormal endocrinologic condition. In 1908, E. Levi published a case in which roentgenograms showed an enlarged and deformed sella turcica, probably due to the presence of a pituitary tumor. H. Cushing reported a case in 1912. Blair Bell, in 1919, and Parkes Weber, in 1921, also published a few cases in . . . [Full Text PDF of this Article]

Author Affiliations
DALLAS, TEXAS

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