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ITS INFLUENCE ON THE INCIDENCE OF RECURRENCE OF RHEUMATIC FEVER IN CHILDREN

MAY G. WILSON, M.D.; MARION G. JOSEPHI, M.D.; DOROTHY M. LANG, M.D.

Am J Dis Child. 1933;46(6):1329-1337.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a previous investigation, it was observed that following treatment with hemolytic streptococcus vaccine, 45 per cent of the treated patients compared with 18 per cent of the subjects of the control series remained free from a recurrence of rheumatic activity for a period of from sixteen months to two years. In discussing the causal relationship between intravenous vaccination and the diminished incidence of recurrence observed, three possibilities were considered:

1. The diminished incidence of recurrence bore no relation to the vaccination, and was merely coincidental.
   
2. Vaccination caused stimulation of antibodies, with resulting increased immunity which was the result of nonspecific protein irritation or of specific immunization with hemolytic streptococci.
   
3. Intravenous vaccination resulted in desensitization of the patient to streptococci, and was not dependent on specific immunization.
   

Author Affiliations
NEW YORK

From the Department of Pediatrics, Cornell University Medical College, and the New York Nursery and Child's Hospital.

Footnotes
This study was conducted under a special grant from the Commonwealth Fund.

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