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A COMPARISON OF THE SCHULTZ-CHARLTON AND CALCIUM BLANCHING TESTS IN SCARLET FEVER

ALFRED E. FISCHER, M.D.; FERDINAND G. KOJIS, M.D.

Am J Dis Child. 1933;46(6):1282-1296.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1918, Schultz and Charlton¹ first reported that the intracutaneous injection of from 0.5 to 1 cc. of normal or scarlet fever convalescent serum would blanch the rash of scarlet fever at the site of injection. They also showed that the blanching substance was present in serum taken after the fourteenth day of scarlet fever, but that serum taken earlier in the disease did not have blanching power. Plain horse serum or diphtheria antitoxin failed to blanch the rash. Schultz and Charlton also made injections of a dilute solution of epinephrine hydrochloride intracutaneously, and found that the rash blanched within a few minutes. This blanching lasted five or six hours. In contrast, the reaction produced by scarlet fever convalescent serum appeared only after five or six hours and lasted several days. Schultz and Charlton expressed the belief that human serum contained some vasoconstricting factor which counteracted the vasodilating effect . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Willard Parker Hospital.

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