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WITH SPECIAL REFERENCE TO THE TIME INTERVAL AND SIZE OF INJECTIONS

PAUL B. KREITZ, M.D.

Am J Dis Child. 1932;44(6):1249-1258.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is not my purpose to discuss the relative merits of toxin-antitoxin and toxoid. This phase has been thoroughly investigated by Ramon and Helie,¹ Zingher,² Bloomberg and Fleming,³ Mozer,⁴ Harrison⁵ and more recently in this clinic by Weinfeld and Cooperstock⁶ and other observers (table 1). The conclusions arrived at by these workers are that toxoid is superior to toxin-antitoxin for the following reasons: 1. Sensitization to horse serum is eliminated. 2. The solution is more stable. 3. Fewer injections are needed. 4. The immunizing power is greater and more rapid.

The original technic as described by Ramon and Helie¹ is as follows:

"An initial dose of 0.5 cc. of anatoxin is injected subcutaneously; three weeks later 1.0 cc. is injected, and in many cases if not all, a third injection of from 1.0 cc. to 1.5 cc. is given fifteen days after the . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH.

From the Department of Pediatrics and Infectious Diseases, University Hospital.

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