This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

CHARLES R. MESSELOFF, M.D.; M. J. KARSH, M.D.

Am J Dis Child. 1932;44(5):999-1006.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Prior to 1912, all the methods available for determining the presence of diphtheria antitoxin in the human blood involved the use of inoculations into guinea-pigs. In that year Schick¹ published the results of his studies on a test with which it was possible to demonstrate the specific antitoxin in the blood and tissues by the simple means of an intracutaneous injection of diphtheria toxin. With this method, now so well known as the Schick test, it became possible to divide human beings into two great classes from the point of view of immunity to diphtheria: (1) those with negative reactions to the Schick test whose blood contained an antitoxin titer of 1/30 unit or more per cubic centimeter of serum and who were immune to clinical diphtheria, and (2) those with positive reactions to the Schick test whose blood contained an insufficient amount of antitoxin and who were liable . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Pediatric Department of Mount Sinai Hospital, Service of Dr. Béla Schick.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?