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THEIR LIMITATIONS AS A MEASURE OF RENAL FUNCTION IN CHILDHOOD

L. EMMETT HOLT, JR., M.D.

Am J Dis Child. 1932;44(2):306-309.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It has been clearly demonstrated by Van Slyke¹ that measurements of urea excretion may indicate impairment of renal function some time before retention of urea in the blood occurs. The most recent modification of the Ambard coefficient—the urea clearance of Van Slyke—is used as a routine procedure in many medical clinics, and is generally regarded as the most sensitive of renal function tests. Although McIntosh, Möller and Van Slyke² presented data on urea clearance in childhood, this test has not come into general use for young children, and the question may well be raised as to whether the pediatrician is not neglecting a valuable and relatively simple procedure.

The purpose of this article is to call attention to certain limitations that affect this test when applied to children, some of which were not emphasized in the publication of McIntosh, Möller and Van Slyke. No new data are presented; . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Harriet Lane Home of the Johns Hopkins Hospital and the Department of Pediatrics of the Johns Hopkins Medical School.

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