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HADDOW M. KEITH, M.B.

Am J Dis Child. 1931;41(3):532-543.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since Wilder,¹ in 1921, suggested the use of a ketogenic diet in the treatment for epilepsy, this procedure has taken a definite place in the treatment for this type of convulsion. The mechanism of the action of this diet, however, is not yet clear. It was suggested by Wilder that the anesthetic action of the ketones produced in the body was the controlling factor. It was also suggested by McQuarrie² that the dehydrating effect of the ketone bodies decreased the susceptibility of the nervous tissue, thereby lessening the frequency of the convulsive attacks.

In order to study the effect of various factors on experimentally produced convulsions, I selected as an active convulsing agent the drug thujone, C₁₀H₁₆O, the chief constituent of the volatile oil of absinthe (wormwood), which has been used by various investigators³ since it was first mentioned by Marce⁴ in . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN.

From the Section on Pediatrics, the Mayo Clinic, Rochester, Minn.

Footnotes
Submitted for publication, Sept. 3, 1930.

Read before the Northwestern Pediatric Society, Rochester, Minn., July 12, 1930.

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