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EDWARDS A. PARK, M.D.; DEBORAH JACKSON, B.S.; LASLO KAJDI, M.D.

Am J Dis Child. 1931;41(3):485-499.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Fifty-six years ago (1874) Wegner¹ showed that inorganic phosphorus administered in small doses, as was formerly the practice in the treatment for rickets, causes the freshly forming trabeculae at the ends of the shafts of the long bones to multiply and become closely packed together. To this dense, thicket-like formation of trabeculae at the end of the shaft induced by phosphorus Wegner gave the name "osteosclerosis." Years later (1918) Phemister² discovered that dense shadows appear in the x-ray photographs of the long bones of children after the administration of minute doses of elementary phosphorus for five weeks or more. These shadows appeared in the parts of the shaft that were in process of growth during the administration of phosphorus and continued to form, so Phemister thought, for a time after the phosphorus had been stopped. Since the long bones grow in length at their ends because of the . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Department of Pediatrics, Johns Hopkins University, School of Medicine and the Harriet Lane Home, Johns Hopkins Hospital.

Footnotes
Submitted for publication, Aug. 16, 1930.

The fact that lead produces these shadows in the x-ray pictures of long growing bones was observed at the same time by Dr. John Caffey of the Department of Pediatrics, Columbia University (personal communication). A report of this phenomenon induced by lead was made by one of us (E. A. P.) in the discussion of a paper by Stafford McLean, "The Bone Lesions of Congenital Syphilis; The Correlation of the Roentgen and Pathologic Observations," and delivered before the Pediatric Section of the New York Academy of Medicine on Nov. 14, 1929. The discussion was published in the AMERICAN JOURNAL OF THE DISEASES OF CHILDREN 39:899 (April) 1930; the article will be published in full in a later issue.

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