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HARTZELL H. RAY, M.D.; JOHN S. CUNNINGHAM, M.D.

Am J Dis Child. 1930;39(6):1205-1213.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Phenylethylhydantoin was introduced under the name "nirvanol"¹ in 1916 as a sedative. The frequent occurrence of severe symptoms such as rash or fever led many authors² to warn against its use. In 1919, Roeder³ recommended phenylethylhydantoin in the treatment for chorea minor.

The reports⁴ were so encouraging that we undertook a study of the action of this drug in a series of cases of chorea. Since chorea is a highly variable disease, no therapeutic study is convincing unless a fairly large number of cases is included, and unless comparison is made with cases in the same series in which the patients were treated by other methods. So far as we are aware, this has not been done previously. This report is based on the study of twenty-five cases; as the children entered the hospital, every other one was treated with phenylethylhydantoin. The dose for younger children . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, N. Y.

From the Department of Pediatrics, the University of Rochester and the Pediatric Service of the Strong Memorial Hospital.

Footnotes
Submitted for publication, Jan. 17, 1930.

Prof. Treat B. Johnson has undertaken the synthesis of homologues of phenylethylhydantoin, which are to be used in the further study of this problem.

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