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A REVIEW OF THE LITERATURE AND REPORT OF A CASE

BENJAMIN M. GASUL, M.D.

Am J Dis Child. 1930;39(3):595-609.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The term diffuse cerebral sclerosis was long applied to a group of diverse diseases characterized by diffuse glial hyperplasia, admittedly the end-result of varied pathologic conditions including inflammatory, degenerative and developmental lesions. In 1912, Schilder¹ isolated from this broad group what he termed a new disease entity, encephalitis periaxialis diffusa, or as it is more commonly termed, Schilder's disease.

His original case was that of a child who presented a confusing clinical picture and died after operation for a presumed cerebral tumor. On the basis of this case and of four other cases that he chose from the literature (those of Ceni,² Rossolimo,³ Beneke,⁴ and Haberfield and Spieler⁵), Schilder characterized the new pathologic entity as a sharply delimited but diffuse subcortical symmetrical involvement of the white matter. The myelin sheaths were destroyed with relative preservation of axones, and secondary hyperplasia of the fibrillary glia took . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Cook County Hospital.

Footnotes
Submitted for publication, Nov. 7, 1929.

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