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A. CLEMENT SILVERMAN, M.D.

Am J Dis Child. 1929;37(5):957-962.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The introduction by Park¹ of the 0.1 L + diphtheria toxin-antitoxin mixture seems to have done away with the possibility of its inducing human hypersensitiveness² to horse serum. Indeed, Bauer and Wilmer³ concluded that hypersensitivity to horse protein is not developed with this mixture; more recently, Spicer⁴ concluded that previous administration of toxin-antitoxin has little if any effect on subsequent treatment with serum and that the danger of sensitization is greatly exaggerated. On the other hand, Stewart,⁵ Gatewood and Baldridge⁶ and Lathrop⁷ reported instances of sensitization to horse serum after injections of toxin-antitoxin, although no evidence is presented that the hypersensitiveness was not present before the administration of the toxin-antitoxin.

The possibility of sensitization has led Hooker⁸ to suggest the use of goat serum in the preparation of toxin-antitoxin, and has given impetus to the use of detoxified toxins. In 1924, Ramon⁹ . . . [Full Text PDF of this Article]

Author Affiliations
SYRACUSE, N. Y.

From the Department of Pediatrics, College of Medicine, Syracuse University and from the Syracuse Health Department and Health Demonstration.

Footnotes
Submitted for publication, Oct. 29, 1928.

Read before the Western New York Branch of the Society for Experimental Biology and Medicine at Rochester, N. Y., May 12, 1928, and since revised for publication.

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