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THE BASE-BINDING POWER OF PROTEINS AND THE DETERMINATION OF TOTAL BASE

DAN C. DARROW, M.D.; ALEXIS F. HARTMANN, M.D.

Am J Dis Child. 1929;37(1):51-60.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recent observations made in different laboratories have emphasized the fact that the total electrolyte content of the blood plasma, and presumably of the body fluids in general, tends to be maintained at a relatively constant level in spite of wide variations in the concentrations of individual ions, and in spite of large fluctuations of plasma water content.

In experimental pyloric obstruction, Gamble and Ross¹ called particular attention to the fact that the total base of the plasma is altered but slightly when enormous reduction of chloride and increase of bicarbonate occur. A similar deduction was made by Hartmann and Smyth² in their study of pyloric stenosis, intestinal obstruction, intestinal fistula and persistent vomiting due to parenteral infections in infants and children. In these conditions, it was apparent that the maintenance of total electrolyte (or fixed base, as expressed by Gamble) took precedence over the maintenance of the normal . . . [Full Text PDF of this Article]

Author Affiliations
WITH THE TECHNICAL ASSISTANCE OF MARIE MORTON ST. LOUIS

From the Department of Pediatrics, Washington University School of Medicine, and the St. Louis Children's Hospital.

Footnotes
Received for publication, July 27, 1928.

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