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SENSITIZATION, SHOCK, BRONCHIAL ASTHMA AND DEATH INDUCED IN THE GUINEA-PIG BY THE NASAL INHALATION OF DRY HORSE DANDER

BRET RATNER, M.D.; HOLMES C. JACKSON, PH.D.; HELEN LEE GRUEHL, B.A

Am J Dis Child. 1927;34(1):23-52.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Several years ago, one of us¹ studied a group of children suffering from bronchial asthma, the cause of which was traced to rabbit hair. In none of these cases was it possible to obtain any hereditary evidence of protein sensitivity; the opinion was therefore expressed at that time that the sensitization had been acquired through the inhalation of dry dust resulting from the rabbit hair which was present in pillows, comfortables, toys, clothing and other articles.

In order to prove this hypothesis, we felt it necessary to produce in an animal a state of protein sensitivity through the direct inhalation of a dry animal emanation, and, further, to reproduce the symptom-complex of bronchial asthma.

MATERIALS AND METHODS USED

In approaching this work, we were confronted with the following considerations: first, the choice of an animal in which this mechanism could be reproduced; second, the necessity of reproducing the entire . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Physiology, University and Bellevue Hospital Medical College, New York University.

Footnotes
Received for publication, Feb. 3, 1927.

This work is being carried on under the "Crane Fund for the Study of Anaphylaxis."

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