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Leslie L. Barton, MD
Department of Pediatrics Steele Memorial Children's Research Center University of Arizona Health Sciences Center 1501 N Campbell Ave Tucson, AZ 85724-5073

C. J. Peters, MD
Atlanta, Ga

Laurie H. Seaver, MD
Greenwood, SC

Stephen A. Chartrand, MD
Omaha, Neb

Arch Pediatr Adolesc Med. 1996;150(4):440.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Lymphocytic choriomeningitis virus (LCMV), an arenavirus perpetuated by chronic infection of mice, has been the agent of sporadic and epidemic disease in Europe and the Americas. Postnatal acquisition of LCMV may be inapparent or associated with systemic or central nervous system manifestations. Congenital LCMV infection, first recorded in England more than 40 years ago,¹ has received virtually no attention outside of Germany² and Lithuania.³ We have recently documented congenital LCMV infection in four infants^4,5 and aided in the diagnosis in two additional neonates. The infection in all infants was manifested by chorioretinitis, hydrocephalus, intracranial calcifications, and psychomotor retardation. Infectious agents excluded by means of culture or serologic examination were Toxoplasma gondii, cytomegalovirus, herpes simplex virus, rubella, Treponema pallidum, mumps virus, human immunodeficiency virus, and enteroviruses. A history of rodent exposure was obtained in three of the four infants whom we personally examined. The diagnosis was confirmed . . . [Full Text PDF of this Article]

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