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Reconciling Town and Gown

Peter C. Rowe, MD; Terry P. Klassen, MD

Arch Pediatr Adolesc Med. 1996;150(4):344-346.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

AFTER SEVERAL decades of controversy, the efficacy of glucocorticoid therapy for children with croup is now substantiated by a consistent body of evidence from randomized controlled trials. Younger clinicians may not appreciate the acrimonious tenor of the corticosteroid-croup debate. As Smith¹ wrote in 1989, "For many years, controversy has been the rule concerning this form of therapy, with battle lines drawn that have primarily, but not exclusively, separated the practitioner and the academician." In general, practitioner opinion favored and academician opinion opposed corticosteroids for croup.

In hindsight, clues about the efficacy of glucocorticoids were present from an early time. One of the first published comparative studies outlined most of the subsequently demonstrated benefits of glucocorticoids in this disease.² A cumulative meta-analysis of the data (Figure) shows that by 1966, glucocorticoids were responsible for clinical improvement 12 hours after treatment (odds ratio, 2.36; 95% confidence interval, 1.75 to 3.18). . . . [Full Text PDF of this Article]

Author Affiliations
Department of Pediatrics The Johns Hopkins University School of Medicine Baltimore, Md; Department of Pediatrics University of Manitoba School of Medicine Winnipeg

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