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Alan H. Jobe, MD, PhD

Arch Pediatr Adolesc Med. 1995;149(6):615-616.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

GARLAND ET al¹ report in this issue that a retrospective observational analysis of multiple possible risk variables for bronchopulmonary dysplasia (BPD) turned up the association of low Pco₂ values before surfactant treatment with BPD. Intuitively, low Pco₂ values suggest better lung function in the preterm infant and might be expected to indicate a decreased risk for BPD. Is the association identified by Garland et al¹ real or the result of data dredging for associations with BPD? Does this observation tell us something important about how we might decrease the incidence of BPD? The association of low Pco₂ values very early in the course of respiratory distress syndrome (RDS) with subsequent BPD is a new observation. Nevertheless, it is consistent with previous associations relating Pco₂ levels to BPD. Avery et al² reported in 1987 that the incidence of BPD was similar across seven . . . [Full Text PDF of this Article]

Author Affiliations
Harbor-UCLA Medical Center Torrance, Calif

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