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Pathological Case of the Month
Stephen A. Heifetz, MD;
Philip R. Faught, MD;
Mark Bauman, MD
Arch Pediatr Adolesc Med. 1995;149(4):464-465.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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A 20-MONTH-OLD mixed-race male toddler, who had been entirely well, was found unresponsive by his mother one morning. Resuscitation by paramedics and emergency department personnel was unsuccessful. An appointment with a private physician for that day had been cancelled because a mild upper respiratory tract infection had resolved.
Significant autopsy findings were confined to the heart, which weighed 53 g (expected, 56 g). The myocardium was slightly pale, but no focal lesions were discernible, even by dissecting microscopy (Figure 1). The left ventricular free wall was 0.9 cm, interventricular septum was 0.8 cm, and right ventricular free wall was 0.2 to 0.3 cm. Light microscopy revealed multiple, small, well-demarcated aggregates of apparently altered cardiac myocytes or Purkinje's cells (Figure 2). Affected cells were polygonal, with abundant granular eosinophilic cytoplasm and few or no myofibers (Figure 3). Occasional individual cells were only partly altered. There was a pronounced predilection for the
. . . [Full Text PDF of this Article]
Author Affiliations
From the Department of Pathology and Laboratory Medicine, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis.
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