This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Leslie L. Barton, MD
Department of Pediatrics Section of Infectious Disease University of Arizona Health Sciences Center Steele Memorial Children's Research Center Tucson, AZ 85724

Arch Pediatr Adolesc Med. 1995;149(3):340-341.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

I am writing in reference to Case 1 of the Pathological Cases of the Month in the July issue of the ARCHIVES.¹ The clinical and pathologic data in this infant support the diagnosis of sinus histiocytosis with massive lymphadenopathy, Rosai-Dorfman disease. Although the patient had serologic tests for a number of viruses, neither serologic testing for human herpesvirus 6 (HHV-6) nor examination of tissue for HHV-6 was performed. In a recent publication, Levine et al² demonstrated the presence of detectable HHV-6 by in situ hybridization in seven of nine patient biopsy specimens examined. Tissue from one patient had detectable Epstein-Barr virus genome and another had no detectable HHV-6 or Epstein-Barr virus. Thus, in some instances, HHV-6, and occasionally Epstein-Barr virus and other viruses, may initiate sinus histiocytosis with massive lymphadenopathy. I also would suggest that the spectrum of pediatric disease caused by infection with Rochalimaea (Bartonella) henselae³ . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?