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Umit Emre, MD; Margaret R. Hammerschlag, MD
Divisions of Pulmonology and Infectious Diseases Department of Pediatrics State University of New York Health Science Center at Brooklyn Brooklyn, NY 11203-2098

Arch Pediatr Adolesc Med. 1995;149(2):220-221.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

We appreciate Hahn's taking the time to read and comment on our recent published study in the ARCHIVES¹; however, we must take exception with some of those comments. Hahn states that we found evidence of C pneumoniae infection in 21 children with reactive airway disease, including nine children who had negative cultures but had "diagnostic" antibody. Unfortunately, diagnostic antibody was also present in 37.5% of the asymptomatic controls with negative cultures, which makes the significance of this antibody questionable. We have found that antibody to C pneumoniae, as determined by the microimmunofluorescence test, is frequently not predictive of who is actually infected as determined by culture and/or polymerase chain reaction.² There are several possible reasons for this. Unlike Chlamydia trachomatis, the major outer membrane protein does not appear to be immunodominant in C pneumoniae infection. The major outer membrane protein appears to be the primary antigen presented . . . [Full Text PDF of this Article]

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