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Salim alikan, MD; Yücel Tadan, MD; Özgür Kasapçopur, MD; Lale Sever, MD; Walter W. Tunnessen, Jr, MD

Arch Pediatr Adolesc Med. 1995;149(11):1267-1268.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

TWO GIRLS, 10 months (Figure 1 and Figure 2) and 18 months of age (Figure 3 and Figure 4), had similar large, annular purpuric skin lesions. Both children were febrile and had edema of their extremities.

Denouement and Discussion

Acute Hemorrhagic Edema of Infancy

Although acute hemorrhagic edema of infancy (AHEI) seems to have been first described by Snow in the United States in 1913,¹ it receives rare notice in the American literature, with most cases reported from Europe.¹ The English-language literature does not include this disorder as a separate entity.²

CLINICAL APPEARANCE

Acute hemorrhagic edema of infancy is a striking disorder similar in many respoects to Henoch-Schönlein purpura (HSP). It is characterized by the sudden appearance of annular and sometimes targetlike purpuric lesions limited almost entirely to the face and extremities, often accompanied by edema and fever. The lesions may begin as urticarial plaques that may enlarge up . . . [Full Text PDF of this Article]

Author Affiliations
From the Divisions of Nephrology (Drs alikan, Kasapçopur, and Sever) and General Pediatrics (Dr Tadan), Cerrahpaa Faculty of Medicine, University of Istanbul, Turkey, and the American Board of Pediatrics, Chapel Hill, NC (Dr Tunnessen).

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