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Agnes Salvador, MD; Debrah Meislich, MD; Walter W. Tunnessen, Jr, MD

Arch Pediatr Adolesc Med. 1994;148(12):1311-1312.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

An infant delivered at 29 weeks' gestation with a birth weight of 1.06 kg was noted to have large, coalescent patches of hypopigmentation that were most prominent on the back (Figure 1). Routine cranial ultrasonography revealed extensive multicystic encephalomalacia (Figure 2). Bilateral chorioretinal scarring and optic atrophy were present on ophthalmologic examination (Figure 3). Results of an electroencephalogram and testing of acoustic and visual evoked reflexes were markedly abnormal.

Denouement and Discussion

Intrauterine Herpes Simplex Virus Infection

DISCUSSION

The estimated incidence of neonatal herpes simplex virus (HSV) infection varies from 1 in 2000 to 1 in 5000 live births in the United States per year.¹ Neonatal HSV disease may involve either the type 1 or 2 virus, with the latter accounting for approximately 75% of the isolates from infected neonates.² The HSV may be transmitted to the fetus or newborn in utero, at the intrapartum stage, or postnatally. Although . . . [Full Text PDF of this Article]

Author Affiliations
From the Divisions of Neonatology (Dr Salvador) and Infectious Disease (Dr Meislich), Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, Pa, and the Department of Pediatrics, The Children's Hospital of Philadelphia (Dr Tunnessen).

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