This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Stefano Mora, MD
Clinica Pediatrica III University of Milan

H San Raffaele
via Olgettina 60 20132 Milan, Italy

Giovanna Weber, MD; Aldo Bellini, MD; Cesare Bianchi, MD; Giuseppe Chiumello, MD
Milan

Arch Pediatr Adolesc Med. 1994;148(11):1215-1217.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Osteopenia is a well-recognized disorder of bone metabolism among premature infants.^{1 -6} Its cause is thought to be complex, with dietary deficiency being a major causative factor. Impairment of bone modeling has also been hypothesized, but extensive studies in infants have not been possible not only because of the invasive procedures required but also because of the lack of specificity of the widely used biochemical indexes of bone formation and resorption. Recently, new specific biochemical markers of bone modeling became available.

Type I collagen accounts for more than 90% of the organic bone matrix.⁷ It is derived from a larger protein, type I procollagen, which has propeptide extensions at both ends of the molecule.⁸ Procollagen type I carboxyterminal propeptide (PICP), a trimeric globular protein, is removed by specific proteinases before collagen molecules are assembled into fibers. Procollagen propeptides are released into circulation in a stoichiometric ratio of . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?