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EDWARD GOLDSON, MD; RANDI J. HAGERMAN, MD
Section of Developmental and Behavioral Pediatrics Department of Pediatrics University of Colorado Health Sciences Center The Children's Hospital 1056 E 19th Ave Denver, CO 80218

Am J Dis Child. 1993;147(6):605-607.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sir.—The fragile X syndrome is the most common form of inherited mental retardation occurring in approximately one per 1000 live births.¹ The disorder is manifested not only by mental retardation or learning disabilities but also by the clearly defined physical characteristics that include large, prominent ears; joint laxity; macro-orchidism; puffiness around the eyes; broad palpebral fissures; and a long, narrow face. There are also cognitive, behavioral, and temperamental characteristics associated with the syndrome.² Autistic features are common, including poor eye contact, perseveration in speech and behavior, and tactile defensiveness, suggesting an increased sensitivity to a variety of stimuli.³ There is also an aberrant approach-withdrawal behavioral pattern in social interactions.⁴ Among the most common physical findings in these individuals is hypotonia and hyperextensibility of the joints, suggesting a connective tissue dysplasia in fragile X syndrome.^2,5 Prolapse of the mitral valve is seen frequently, and the . . . [Full Text PDF of this Article]

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