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DENISE M. ADAMS, MD; PAUL C. YOUNG, MD; KENNETH C. COPELAND, MD
Department of Pediatrics University of Vermont College of Medicine Given Bldg Burlington, VT 05405-0068

Am J Dis Child. 1992;146(10):1132-1133.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.—We appreciate the opportunity to respond to the letter pertaining to our article.¹ Indeed, we were delighted to see the publication of age-specific corticotropin stimulation data² that appeared in print only after our article was submitted. These normative data confirm our suspicions that the increased ⁵-17-hydroxypregnenolone and ⁵-17-hydroxypregnenolone—17-hydroxyprogesterone ratios observed in our patients and those of Oberfield et al³ may have reflected "a normal delay in fetal adrenal-zone involution." We agree entirely that decreased 3β-hydroxysteroid activity in infancy is inadequately appreciated, and normative data such as those of Lashansky et al² will be of benefit in increasing recognition of this developmental phenomenon.

Unfortunately, we still can only speculate on the origin (or origins) of pubic hair development in infancy. As stated, we suspect that some cases may reflect increased sensitivity of pubic hair follicles to normal androgen levels, since pubic hair development . . . [Full Text PDF of this Article]

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