
Lead Poisoning in Children With Developmental Disabilities
STEPHEN B. SULKES, MD
University Affiliated Program for Developmental Disabilities University of Rochester Medical Center Rochester, NY 14642
DENNIS W. O'CONNOR, MD
Keuka Family Practice Associates Bath, NY 14810
Am J Dis Child. 1991;145(6):602.
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Sir.—We were pleased to read the article by Friedman and Weinberger1 in the September 1990 issue of AJDC regarding the screening, diagnosis, and treatment of children with lead poisoning. We describe a child with mental retardation whose pica behavior led to lead poisoning.
Patient Description.—An 8-year-old boy with previously diagnosed infantile autism and mental retardation underwent interdisciplinary team evaluation. The medical history incorporated questions regarding stereotypic behaviors, specifically pica. With confirmation of pica, a lead level of 3.13 µmol/L and an erythrocyte protoporphyrin level of 364 µg/dL were measured. Lead-based paint was discovered in the home of the boy's grandparents. He received chelation treatment with intramuscular calcium disodium ethylenediaminetetraacetic acid (EDTA) and oral penicillamine on an outpatient basis. His lead level dropped to 1.45 µmol/L. Repeated developmental testing 4 years later showed performance at the 8-month level in language skills and at the 2- to 3-year level
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