• Online Features  This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (1)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

JÉRÔME LEJEUNE, MD, PHD; MARIE PEETERS, MD; MARIE ODILE RETHORE, MD; MARIE CHRISTINE DE BLOIS, MD
Centre de Recherches Génétique Humaine et Maladies de l'Intelligence Institut de Progenèse 45, rue des Saints-Pères 75270 Paris cedex 06 France

JEAN PIERRE DEVAUX, MD
Service Central des radio-isotopes Hôpital des Enfants Malades 149, rue de Sèvres 75743 Paris cedex 15 France

Am J Dis Child. 1990;144(1):19.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sir.—Since publications cross geographic but only rarely linguistic boundaries, we wish to bring to your attention our recent publication on elevated thyrotropin (TSH) levels and Down syndrome (DS).¹

Our findings are in accordance with those observed by Sharav et al.²

A prospective survey was carried out on 78 patients with DS (age range, 6 months to 16 years; mean, 9.08±6.99 years) followed up at our genetics clinic, Hopital des Enfants Malades, Paris, France. The TSH levels were significantly elevated (t = 9.5; P<<<.001) in the group with trisomy 21 (3.99±2.54 mU/L) as compared with 214 age-matched normal children (2.01±0.85 mU/L). There was no difference in free thyroxine (T₄) levels between both groups (trisomy 21, 20.55±3.81 pmol/L; controls, 21.12±3.19 pmol/L). Free triiodothyronine (T₃) levels, however, tended to be lower in the DS group (7.09±1.68 pmol/L) vs controls (7.92±1.39 pmol/L) (t=2.4; P=.05).

We observed a . . . [Full Text PDF of this Article]

Footnotes

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?