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JEROME R. KRAUT, MD; BHARATI SHAH, MD
Division of Pediatrics Section of Gastroenterology and Nutrition Lutheran General Hospital 1775 Dempster St Park Ridge, IL 60068

Am J Dis Child. 1989;143(8):881-882.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sir.—The diagnostic features of benign transient hyperphosphatasemia are (1) patient age of less than 5 years; (2) variable, usually unrelated symptoms; (3) no physical evidence for bone or liver disease; (4) no other biochemical or laboratory evidence for bone or liver disease (including normal isoenzymes, if test is done); and (5) a return to normal serum alkaline phosphatase level within 4 months with no sequelae.¹ The cause is unknown but proposed mechanisms include malnutrition, drug induction, viral infection, and transient impeded clearance of serum alkaline phosphatase.¹ The two patients described herein are, to our knowledge, the first set of twins who developed the syndrome simultaneously.

Patients and Methods.—These 11-month-old white male twins were well until an age of 9 months, when they developed severe diarrhea. Stool cultures from both were positive for Salmonella. No antibiotics were given. They continued to have frequent loose stools over the . . . [Full Text PDF of this Article]

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