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Reconsideration of IgM-Enriched Intravenous Immunoglobulin for Neonatal Sepsis
SUE L. HALL, MD
The Children's Mercy Hospital Section of Neonatal/Perinatal Medicine 24th at Gilham Road Kansas City, MO 64108
Am J Dis Child. 1989;143(7):766.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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To the Editor.—In the article by Haque et al1 in the December 1988 issue of AJDC, the authors concluded that mortality from neonatal sepsis (suspected or proved) was significantly reduced in a group of 30 infants treated in a prospective, randomized trial with IgM-enriched intravenous immunoglobulin (Pentaglobin, Biotest Pharma, Frankfurt, West Germany) in addition to antibiotics compared with a control group of 30 infants who were treated with antibiotics alone.
Their conclusion of a statistically significant (P<.001) reduction in mortality between the treated and control groups was based on the use of Student's t test for statistical analysis. Is there some rationale that makes use of the Student t test the appropriate test for analysis of these outcome data?
As outcome is a discrete and not a continuous or numerical parameter, a t test, which is a parametric test of the difference in means between two samples
. . . [Full Text PDF of this Article]
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