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ARLAN L. ROSENBLOOM, MD; CAROLE L. KNUTH, PA-C
Department of Pediatrics University of Florida College of Medicine PO Box J-296 J. Hillis Miller Health Center Gainesville, FL 32610

Am J Dis Child. 1989;143(6):642-643.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sir.—The optimal dosage of growth hormone (GH) for the treatment of GH deficiency has not been determined. As little as 2.5 U given once weekly can result in catch-up growth.¹ Raben² established a dosage of 2 U three times per week regardless of body size as the standard that was used into the 1980s. In a series of reports the US Collaborative Study Group concluded that a dosage of 0.06 U/kg of body weight three times per week was appropriate. These and other studies were summarized by Frasier³ in a comprehensive review. He developed a log-dose response curve, based on the published data, that had a very shallow slope, indicating a decreasing cost benefit of increasing dosage.

The purpose of this study was to compare what had been a relatively high dosage of pituitary extract GH (0.12 U or 0.06 mg/kg three times per week) recommended by one manufacturer . . . [Full Text PDF of this Article]

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