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Report of Two Cases in Children, With Necropsy in One Case

V. P. Sydenstricked [sic], M.D.; W. A. Mulherin, M.D.; R. W. Houseal, M.D.

Am J Dis Child. 1987;141(6):612-615.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

J. B. Herrick,¹ in 1910, reported a peculiar dyscrasia characterized by severe anemia, with the occurrence in the blood of elongated and sickle-shaped erythrocytes. Three instances of this condition have since been described, one by R. E. Washburn;² one by Cook and Myer,3 and one by V. R. Mason.⁴ Emmel⁵ further studied the blood of Cook and Myer's case, demonstrating the existence of phagocytosis of the erythrocytes by large mononuclear leukocytes in the peripheral circulation. He also pointed out the fact that when sealed sterile preparations of the fresh blood were allowed to stand at room temperature for varying periods of time, many of the circular erythrocytes underwent transformation into elongated and sickle shapes similar to those seen in the freshly drawn blood. Furthermore, he showed that the blood of the patient's father, though normal to all appearances when drawn, underwent similar changes on standing. Guthrie . . . [Full Text PDF of this Article]

Author Affiliations
Augusta, Ga.

*From the department of internal medicine, University of Georgia Medical Department.

Footnotes
*Received for publication, May 31, 1923.

1. Herrick, J. B.: Peculiar Elongated and Sickle-Shaped Red Blood Corpuscles in a Case of Severe Anemia, Arch. Int. Med. 6:517 (Nov.) 1910.

2. Washburn, R. E.: Peculiar Elongated and Sickle-Shaped Red Blood Cells in a Case of Severe Anemia, Virginia Med. Semimonthly, 15:490, 1911.

3. Cook, J. E., and Myer, J.: Severe Anemia with Remarkable Elongated and Sickle-Shaped Red Blood Cells and Chronic Leg Ulcers, Arch. Int. Med. 16:644 (Oct.) 1915.

4. Mason, V. R.: Sickle Cell Anemia, J. A. M. A. 69:1318 (Oct. 14) 1922.

5. Emmel, V. E.: A Study of the Erythrocytes in a Case of Severe Anemia with Elongated and Sickle-Shaped Red Blood Corpuscles, Arch. Int. Med. 20:586 (Oct.) 1917.

6. Guthrie, C. G., and Huck, J.: On the Existence of More than Four Iso-Agglutinin Groups in Human Blood, Bull. Johns Hopkins Hosp. 34:43 (Feb.) 1923.

7. Dresbach, M., quoted by Bishop, F. W.: Elliptical Human Erythrocytes, Arch. Int. Med. 14:388 (Sept.) 1914.

8. Bishop, F. W.: Footnote 7.

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