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Cornelia Cho, MD; Albert W. Pruitt, MD; James J. Corrigan, Jr, MD; Hugh D. Allen, MD; Richard Hong, MD; C. Thomas Kisker, MD

Am J Dis Child. 1986;140(4):360-366.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Calcium channel—blocking drugs, also referred to as calcium antagonists and slow-channel blockers, have had a major impact on the treatment of cardiovascular disorders such as angina, arrhythmias, and hypertension in adults. Although the drugs are labeled for use in only a limited number of pathologic conditions in children, clinical evaluations in a variety of illnesses are under way. Among the exciting potential uses are the treatment of asthma, control of premature labor, and as adjunctive therapy in cancer chemotherapy. The purpose of this report is to review research that has relevance to the therapeutic application of calcium channel blockers in the young.

PHARMACOLOGY

Calcium and its regulation are vital to a wide range of physiologic functions, including myocardial contractility, nerve impulse transmission, smooth-muscle contraction, and secretory activity of exocrine glands. An essential role for calcium was suggested by Ringer^1,2 in 1883, when he demonstrated that the addition of calcium . . . [Full Text PDF of this Article]

Author Affiliations
Tucson; Tucson; Madison, Wis; Iowa City

From the Department of Pediatrics, Medical College of Georgia, Augusta.

Footnotes
Accepted for publication Dec 3, 1985.

Reprint requests to Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 (Dr Pruitt).

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