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NURTEN KOÇAK, MD; INASI ÖZSOYLU, MD; FAIK SARIALIOGLU, MD; NESRIN GOKSU, MD
Hacettepe University Ankara, Turkey

Am J Dis Child. 1985;139(9):858.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sir.—Association between hepatitis B surface antigen (HBsAg) and hepatocellular carcinoma (HCC) has been strongly suggested by Szmuness,¹ and integrated hepatitis B virus DNA (HBV-DNA) has been demonstrated in human HCC cell lines.² It has also been strongly suggested that HCC patients acquire hepatitis B virus from their mothers during the perinatal period in populations with a high HBsAg prevalence. To our knowledge, this association has been reported only in adults, more in men than in women.

Patient Report.—A 10-year-old Turkish boy had HCC in whom HBsAg was present but in whom anti–HBs remained negative. He was seen in this hospital on Sept 21, 1984, because of a protuberant abdomen, lassitude for 1 months' duration, and recent jaundice. He was underdeveloped, cachectic (weight, 24 kg; height, 125 cm; both values less than third percentile), and jaundiced. The liver was markedly enlarged with several very hard masses. The spleen . . . [Full Text PDF of this Article]

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