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SINASI ÖZSOYLU, MD; NEJAT AKGÜN, MD
Department of Pediatrics Hacettepe University Ankara, Turkey

Am J Dis Child. 1985;139(1):10.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sir.—We read with interest the article by Maggiore et al¹ entitled "Defective Neutrophil Motility in Children With Chronic Liver Disease."

Since defective neutrophil motility was primarily shown in children with chronic active hepatitis and chronic persistent hepatitis, we would like to note that defective chemotaxis has previously been reported in cirrhotic patients.² Defective neutrophil chemotaxis has also been shown in cirrhotic children (mean±SD, 51.9±16.2 µm v 73.1±14.1 µm; P<.001) in our department. This finding was correlated with the neutrophil zinc level (0.0083 ± 0.0027 µg/10⁶ cells v 0.0134 ±0.0033 µg/10⁶ cells; P<.001), without any difference in neutrophil random migration. This chemotactic defect was basically corrected when the patients' neutrophils were incubated with control serum samples or zinc (0.05 mL of neutrophil mixture and 1 µg of zinc), but the patients' serum samples in general had an inhibitor effect on control neutrophil chemotaxis (N.A. . . . [Full Text PDF of this Article]

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