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LT COL DANIEL L. COHEN, MC

Am J Dis Child. 1983;137(3):289-290.

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Sarcoidosis is a chronic, often debilitating, granulomatous, multiple-system disorder that commonly affects adults but only occasionally occurs in childhood. Although it has been previously described as a rare pediatric disease, recent studies have suggested that the incidence of asymptomatic disease may be substantial in certain population groups.¹ Pulmonary infiltration and hilar lymphadenopathy are the most frequently encountered early manifestations of sarcoidosis, although cutaneous and ophthalmologic symptoms (uveitis) may also occur in some patients.^2,3 The clinical diagnosis is one of exclusion and must be confirmed by a positive Kveim-Siltzbach skin test or by histopathologic evidence of widespread noncaseating epithelioid granulomas in more than one organ.⁴

The syndrome of keratoconjunctivitis sicca, xerostomia, and salivary gland adenopathy is an unusual isolated manifestation of sarcoidosis and may be confused with Sjögren's syndrome,⁵ a chronic autoimmune disorder related to rheumatoid arthritis and occasionally associated with malignant lymphoproliferative disease. Histologic differentiation of . . . [Full Text PDF of this Article]

Author Affiliations
USAF Uniformed Services University of the Health Sciences Bethesda, Md

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