• Online Features  This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

JACOB V. ARANDA, MD, PHD; EUGENE W. OUTERBRIDGE, MD; JEROME J. SCHENTAG, PHARMD

Am J Dis Child. 1983;137(12):1207.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Cimetidine, an H₂ receptor antagonist, is currently widely used to block gastric acid secretions in adult patients with peptic ulcers and to prevent stress ulceration and subsequent bleeding in critically ill or traumatized patients.¹ It has also been used in newborns,² despite lack of information on the pharmacologic effects and kinetic disposition of this drug in this age group. We, therefore, report the plasma elimination of this drug and its effect on gastric acid secretions in a premature neonate.

Report of a Case.—A 660-g female infant was born at 25 weeks' gestation. The first three weeks of life were complicated by severe apnea, bradycardia, and respiratory distress requiring mechanical ventilation. Congestive heart failure caused by a patent ductus arteriosus was also noted; it responded to diuretics and two courses of indomethacin and chloroquine phosphate. She received total parenteral nutrition. Impaired renal function was noted, presumably caused . . . [Full Text PDF of this Article]

Author Affiliations

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?