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Solutions Infused—Lessons Learned

Lewis D. Stegink, PhD

Am J Dis Child. 1983;137(10):1008-1016.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The history of parenteral nutrition has been reviewed recently by several investigators.^1-4 Thus, my summary will be brief and draw heavily on those reviews.

HISTORY

To my knowledge, the first recorded intravenous (IV) infusion occurred as early as 1656 when Sir Christopher Wren injected solutions of "nutrients" and drugs into dogs. For this purpose, he used a goose quill attached to a pig's bladder and infused solutions containing ale, opium, and wine.⁵ Soon afterward, Major⁶ and Lower and King⁷ infused solutions and carried out blood transfusions in animals. In 1667, Denis⁸ transfused blood from a lamb into a human. These latter experiments might be considered the first use of infusions that provided an amino acid source. Since nothing was known about microorganisms, sterility, immunologic incompatibility, osmolality, or pyrogens, it is not surprising that a large number of complications and deaths resulted.

Technical improvements followed, and . . . [Full Text PDF of this Article]

Author Affiliations
From the Departments of Pediatrics and Biochemistry, University of Iowa College of Medicine, Iowa City.

Footnotes
Reprint requests to Department of Pediatrics, S385 Hospital School, University of Iowa, Iowa City, IA 52242 (Dr Stegink).

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